Go to: Smoking Smoking has been shown in several studies to be positively associated with an increased risk of ED. Longitudinal epidemiologic studies have reported a relative risk of developing ED 1.5–2 times more in smokers in comparison prostate cancer treatment dallas texas to non-smokers (7,8,26,27). In the Boston Area Community Health survey, a cross-sectional study of 2,301 men, a dose-response relationship prostate cancer treatment dallas texas was demonstrated between smoking and ED (28). Significance was achieved at 20-pack years cumulative exposure after adjusting for risk factors of age, CVD, and diabetes. Though not found to be significant, passive smoking exposure trended toward a significant risk of ED. While this study design is subject to recall bias, it may provide important information when quantifying risk of
Prostate cancer treatment dallas texas ED due to smoking exposure. Positive dose-response association prostate cancer treatment dallas texas between quantity and duration of smoking with risk of ED was prostate cancer treatment dallas texas confirmed in a meta-analysis of observational epidemiologic studies (29). The investigators found an incremental increased risk of ED per 10 cigarettes smoked per day and 10 years of smoking, by 14% and 15%, respectively. An individualized inverse dose-response relationship was seen in male smokers undergoing polysomnographic assessment of nocturnal penile tumescence (NPT), where the highest consumers of cigarettes (>40 cigarettes
Per day) had the fewest minutes of nocturnal tumescence and detumesced fastest (30). At a molecular and cellular level in the animal model, cigarette smoking (CS) is linked to significantly higher markers of oxidative stress and cavernosal tissue apoptosis (31). CS
Prostate cancer treatment dallas texas exposed rats were noted to have significantly lower expression of cavernosal neuronal nitric oxide synthase (nNOS) and decreased prostate cancer treatment dallas texas endothelial and smooth muscle content, supporting the role of endothelial dysfunction prostate cancer treatment dallas texas in pathophysiology of ED (12).
The effect of smoking cessation on erectile function has also been examined. prospectively studied a sample of prostate cancer treatment dallas texas men with ED and smoking as their only risk factor; excluded were prostate cancer treatment dallas texas men with other risk factors for ED such as diabetes, hypertension, dyslipidemia, peripheral vascular disease, psychiatric disorders, and renal failure. At baseline,
Severity of ED was found to be significantly correlated to duration of exposure in pack-years (32). At follow-up prostate cancer treatment dallas texas 1 year after smoking cessation, patients who successfully prostate cancer treatment dallas texas stopped smoking (ex-smokers) had a 25% improvement in erectile function, while men who continued (current smokers) did not improve.
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Cilexin |
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